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An out-and-out Comedy, Sisters is a story of two quirky adult sisters, Kate and Maura. In what can be called a textbook case of opposites, Maura is a recently divorced kind-hearted nurse who is always on the lookout to help others, while Kate is an unruly, brash and unorganized single mother who works as a stylist. Otherwise living very separate lives, the two sisters are brought together at their old family when they are summoned to gather their old belongings as their parents have decided to sell it.

Surprised and disappointed, the sisters decide to make their last days in their family home memorable as they decide to throw one last wild party for their classmates. However, everything does not go according to plan as their party turns dangerously awry. What ensures is a night full of disasters and mayhem, as one failed event leads to another.

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